Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease
Identifieur interne : 001F52 ( Main/Exploration ); précédent : 001F51; suivant : 001F53Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease
Auteurs : RUKSANA AZHU VALAPPIL [États-Unis] ; Jed E. Black [États-Unis] ; Meredith J. Broderick [États-Unis] ; Oscar Carrillo [États-Unis] ; Eric Frenette [Canada] ; Shannon S. Sullivan [États-Unis] ; Samuel M. Goldman [États-Unis] ; Caroline M. Tanner [États-Unis] ; James W. Langston [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.
Affiliations:
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Langston</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0491583</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0491583 INIST</idno><idno type="RBID">Pascal:10-0491583</idno><idno type="wicri:Area/PascalFrancis/Corpus">000846</idno><idno type="wicri:Area/PascalFrancis/Curation">002473</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A69</idno><idno type="wicri:doubleKey">0885-3185:2010:Ruksana Azhu Valappil:exploring:the:electrocardiogram</idno><idno type="wicri:Area/Main/Merge">002656</idno><idno type="wicri:Area/Main/Curation">001F52</idno><idno type="wicri:Area/Main/Exploration">001F52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease</title><author><name sortKey="Ruksana Azhu Valappil" sort="Ruksana Azhu Valappil" uniqKey="Ruksana Azhu Valappil" last="Ruksana Azhu Valappil">RUKSANA AZHU VALAPPIL</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Black, Jed E" sort="Black, Jed E" uniqKey="Black J" first="Jed E." last="Black">Jed E. Black</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1><s2>Redwood City, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Broderick, Meredith J" sort="Broderick, Meredith J" uniqKey="Broderick M" first="Meredith J." last="Broderick">Meredith J. Broderick</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Sleep Medicine, Minor & James Medical</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Carrillo, Oscar" sort="Carrillo, Oscar" uniqKey="Carrillo O" first="Oscar" last="Carrillo">Oscar Carrillo</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1><s2>Redwood City, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Frenette, Eric" sort="Frenette, Eric" uniqKey="Frenette E" first="Eric" last="Frenette">Eric Frenette</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, University of Sherbrooke</s1><s2>Sherbrooke, Quebec</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sherbrooke, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Sullivan, Shannon S" sort="Sullivan, Shannon S" uniqKey="Sullivan S" first="Shannon S." last="Sullivan">Shannon S. Sullivan</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1><s2>Redwood City, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Langston, James W" sort="Langston, James W" uniqKey="Langston J" first="James W." last="Langston">James W. Langston</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dysfunction</term><term>Electrocardiography</term><term>Heart rate</term><term>Medical screening</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Variability</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Electrocardiographie</term><term>Dépistage</term><term>Rythme cardiaque</term><term>Variabilité</term><term>Trouble fonctionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Ruksana Azhu Valappil" sort="Ruksana Azhu Valappil" uniqKey="Ruksana Azhu Valappil" last="Ruksana Azhu Valappil">RUKSANA AZHU VALAPPIL</name></region><name sortKey="Black, Jed E" sort="Black, Jed E" uniqKey="Black J" first="Jed E." last="Black">Jed E. Black</name><name sortKey="Broderick, Meredith J" sort="Broderick, Meredith J" uniqKey="Broderick M" first="Meredith J." last="Broderick">Meredith J. Broderick</name><name sortKey="Carrillo, Oscar" sort="Carrillo, Oscar" uniqKey="Carrillo O" first="Oscar" last="Carrillo">Oscar Carrillo</name><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name><name sortKey="Langston, James W" sort="Langston, James W" uniqKey="Langston J" first="James W." last="Langston">James W. Langston</name><name sortKey="Sullivan, Shannon S" sort="Sullivan, Shannon S" uniqKey="Sullivan S" first="Shannon S." last="Sullivan">Shannon S. Sullivan</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name></country><country name="Canada"><noRegion><name sortKey="Frenette, Eric" sort="Frenette, Eric" uniqKey="Frenette E" first="Eric" last="Frenette">Eric Frenette</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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